The town of Granger began as a stage stop on the transcontinental stage line that followed the Oregon Trail in the 1850's. There was also a Pony Express station here while that noble enterprise was in operation. In 1861, Ben Holladay bought the stage line and renamed it the Central Overland Express. To avoid Indian troubles on the northern plains, Holladay changed the route a bit further to the south, crossing the Continental Divide at Bridger's Pass and then following Bitter Creek to the Green River. At that point, the stage line followed the same route as today's I-80, crossing the Green River and then following Black's River to where it met up again with the old Oregon Trail at Granger, near the confluence of Muddy Creek and Black's River.

William Henry Jackson (the famous photographer) spent 3 weeks at the Granger Stage Station in 1866, waiting to join a wagon train headed for Salt Lake City. The Union Pacific Railroad arrived in 1868 and that ended the stage business in Granger.

These days, Granger plays host to the Moxa Arch Gas Field where BP operates 450 natural gas wells that produce more than 1 MCF of natural gas per day.